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Advances in Dementia Research by D. Inzitari, G. Carlucci, Leonardo Pantoni MD. PhD (auth.),

By D. Inzitari, G. Carlucci, Leonardo Pantoni MD. PhD (auth.), Prof. Dr. K. Jellinger, Prof. Dr. R. Schmidt, Dr. M. Windisch (eds.)

Dementia is an enormous ailment that turns into more and more universal with advancing age. regardless of fresh development in neurobiology and molecular genetics, the aetiology and pathogenesis of so much dementia issues are nonetheless poorly understood, and early specified prognosis as a prerequisite of powerful remedy should be enhanced. the current quantity contains the contributions of well known specialists within the box of neurodegeneration offered on the foreign Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging concepts, and the function of vascular, immunological and different mechanisms together with oxidative rigidity and estrogens within the improvement of neurodegeneration and dementia. fresh advancements in analysis and treatment of Alzheimer affliction and similar problems are reviewed and destiny healing ways are mentioned. therefore, this quantity offers a well timed evaluate of latest advancements in dementia study and therapy recommendations of dementia disorders.

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Department of Psychiatry, Sahlgrenska University Hospital, SE-413 45 Goteborg, Sweden Novel imaging technologies in the assessment of cerebral ageing and vascular dementia F. Fazekas1,2, S. Ropele 1,2, R. Bammer1,2, P. Kapeller1,2, R. Stollberger2, and R. Schmidt1,2 1 Department of Neurology, Karl-Franzens University, Graz, Austria 2MR Center, Karl-Franzens University, Graz, Austria Summary. Introduction of magnetic resonance imaging (MRI) has opened new possibilities for detecting age-related brain tissue changes.

Diabetologia 39: 1392-1397 Ott A, Breteler MMB, de Bruyne MC, van Harskamp F, Grobbee DE, Hofman A (1997) Atrial fibrillation and dementia in a population-based study. The Rotterdam Study. Stroke 28: 316-321 Ott A, Slooter AJ, Hofman A, van Harskamp F, Witteman JC, Van Broeckhoven C, van Duijn CM, Breteler MM (1998) Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study. Lancet 351: 18401843 Pasquier F, Leys D (1997) Why are stroke patients prone to develop dementia?

Dementia is not always present in patients with a lacunar state. , 1980; Pantoni and Garcia, 1995). However, the existence of Binswanger's disease as a specific type of vascular dementia (V aD) remains controversial (Pantoni and Garcia, 1995). Dementia may occur after several strokes, when patients have dysarthria, dysphagia, "marche a petits pas", incontinence, spasmodic laughing or crying, and parkinsonism. In other cases, multiple brain infarcts are recognized on brain imaging, in patients with dementia and no clear clinical evidence of stroke.

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