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Brain damage and repair : from molecular research to by T. Herdegen, J. Delgado-Garcia

By T. Herdegen, J. Delgado-Garcia

This publication builds a singular bridge from molecular learn to medical remedy. This method finds the useful good points of neurons and glia within the specific context of vulnerability and self-protection, intracellular houses and extracellular matrix. bobbing up from this platform, this quantity unfolds the molecular and systemic strategies underlying migration problems, axonal damage, fix and regeneration.

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Elsevier, Amsterdam, Boston, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo, 2002. J. (2000) deltaFosB: a molecular switch underlying long-term neural plasticity. Current Opinion in Neurolology 13, 715-720. A. (2002) Gene silencing in mammals by small interfering RNAs. Nature Reviews Genetics, 3, 737-742. T. (2002) A decade of molecular studies of fragile X syndrome. Annual Reviews of Neuroscience, 25, 315-338. 2. , Reinberg D. (2002) Review: A unified theory of gene expression.

Bar = 50µm. d) multipolar motoneurone in the spinal cord, showing prominent cytoplasmic Nissl bodies. Small dark spots in the cytoplasm correspond to lysosomes and similarly sized faint grey spots in dendrites correspond to mitochondria. Bar = 20µm 3. MORPHOLOGICAL PECULIARITIES OF THE NEURON 35 The ability of the axons of neurones to take up and transport trophic as well as toxic materials from their terminal fields to the cell body makes this a useful classification for neuropathological studies.

Annual Reviews of Neuroscience, 25, 315-338. 2. , Reinberg D. (2002) Review: A unified theory of gene expression. Cell, 108, 439-445. Steward O, Schuman EM. (2001) Protein synthesis at synaptic sites on dendrites. Annual Reviews of Neuroscience 24, 299-325. I. P. JOHNSON University College Medical School, London, UK 3. MORPHOLOGICAL PECULIARITIES OF THE NEURON Summary. This chapter gives an overview of the morphological features of neurones that distinguish them from other cells, allow them to carry out their unique function in the body.

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