Brain Tumors in Adults, An Issue of Neurologic Clinics by Patrick Wen MD, David Schiff MD

By Patrick Wen MD, David Schiff MD

In 2007, among 40.000 and 50,000 humans within the usa may be clinically determined with fundamental mind tumors, nearly all of whom may be adults. 3 times this quantity will increase metastatic mind tumors from melanoma originating somewhere else within the physique. This factor of Neurologic Clinics includes the subsequent articles: Epidemiology of mind Tumors (Wrensch, Claus); Molecular Pathogenesis of mind Tumors and the position of Stem Cells (Ligon, Kesari); Advances in Neuroimaging of mind Tumors (Henson); clinical administration of mind Tumor sufferers (Schiff, Wen); Advances in Neurosurgery for mind Tumors (Shaffrey); Advances in Radiation treatment for mind Tumors (Mehta); Novel cures for mind Tumors (Wen, Schiff); Anaplastic Astrocytomas and Glioblastomas (Reardon); Anaplastic Oligodendrogliomas and Anaplastic Oligoastrocytomas (Van Den Bent); Low-Grade Gliomas (Lang, Gilbert); mind Metastases (Deangelis); Benign mind Tumors (Link); basic CNS Lymphoma (Abrey); and Genetic factors of mind Tumors (Plotkin).

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Without recognition of these needs, patients can leave physician encounters with a treatment plan for their CNS metastases, but without a mechanism for managing their new level of function. Occult brain metastases Of growing interest and frequency is the acquisition of brain imaging to screen for brain metastases before starting treatment in a patient who has no neurologic symptoms. In some instances, asymptomatic patients are screened to qualify for enrollment in a clinical trial. Most therapeutic trials exclude patients who have CNS involvement because it carries a poor prognosis, and certain investigational agents, such as the new angiogenesis inhibitors, may have a theoretic increased risk of hemorrhage.

Am J Roentgenol Radium Ther Nucl Med 1971;111(2):334–6. [26] Kurtz JM, Gelber R, Brady LW, et al. The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981;7(7):891–5. [27] Pease NJ, Edwards A, Moss LJ. Effectiveness of whole brain radiotherapy in the treatment of brain metastases: a systematic review. Palliat Med 2005;19(4):288–99. [28] DeAngelis LM, Mandell LR, Thaler HT, et al. The role of postoperative radiotherapy after resection of single brain metastases.

6 months. 5%. Treatment was well tolerated, with grade 3 and 1144 CAVALIERE et al 4 toxicity occurring in less than 10% of patients [8]. This study led to Food and Drug Administration approval of temozolomide for patients who have newly diagnosed GBM. The optimal duration of adjuvant temozolomide following radiotherapy remains unknown. In the EORTC trial, six cycles of adjuvant temozolomide were administered following radiotherapy. Yet it is common practice in the United States to continue temozolomide for a longer duration.

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