Economic Theory

Growth Factors in Development by Carmen Birchmeier (Eds.)

By Carmen Birchmeier (Eds.)

This new quantity of the popular serial present issues in Developmental Biology covers the real positive aspects of development elements in improvement. With a global board of authors, this quantity might be useful for researchers in cellphone, developmental and molecular biology.Provides researchers an outline and synthesis of the newest examine findings and modern proposal within the areaThis quantity offers an up to date and well timed viewpoint

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Even though the detailed mechanisms of these 30 Tina Buechling and Michael Boutros lately identified Wnt regulators remains vague, they might be suitable entry points for the development of therapeutics in b-catenin-driven malignancies. 3. 1. Wnt proteins and their posttranslational modifications Wnt proteins constitute a large family of structurally related cysteine-rich glycoproteins with an approximate molecular weight of 38–42 kDa. To date, 19 different Wnts have been identified in mouse and human, 15 in zebrafish, 5 in C.

1. Post-Golgi transport of Wnt proteins In recent years, progress has been made to identify components required for processing and secretion of active Wnt proteins (reviewed in Bartscherer and Boutros, 2008; Lorenowicz and Korswagen, 2009; Port and Basler, 2010). Wnt secretion has to be tightly regulated as Wnt proteins regulate cellular processes in surrounding tissues and determine cell fate in a concentration dependent manner. All Wnt proteins contain an N-terminal hydrophobic signal peptide for transport through the secretory pathway (Fig.

Natl. Acad. Sci. USA 92, 1431–1435. , and Salzer, J. L. (2006). Axonal regulation of myelination by neuregulin 1. Curr. Opin. Neurobiol. 16, 492–500. , and Trembleau, A. (2005). Morphological and molecular features of the mammalian olfactory sensory neuron axons: What makes these axons so special? J. Neurocytol. 34, 49–64. , and Birchmeier, C. (2010). Nrg1/ErbB signaling networks in Schwann cell development and myelination. Semin. Cell Dev. Biol. 21, 922–928. , Saunders, T. , and Morrison, S. J.

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